What is Rhodiola rosea? - old

Rhodiola Supports Brain Health

Antioxidants are vital to defending the brain against damaging oxidative stressors. The antioxidants within Rhodiola rosea support neuroprotection in multiple ways.

  • Supports Stress and Burnout Reduction – One research study found that participants who took Rhodiola rosea for 4 weeks had reported significantly improved stress levels and reduced fatigue [5]. Elevated stress levels over a long period can lead to burnout and mental exhaustion. Remarkably, studies have found clinically significant improvements in burnout with Rhodiola rosea supplementation [6].
  • Supports Memory & Focus – Recent studies suggest that Rhodiola rosea may beneficially alter brain chemistry and improve blood flow to the brain, ultimately protecting brain cells [7]. These neuroprotective qualities indicate that Rhodiola rosea may maintain and support memory, focus, and learning.
  • Supports Mood & Wellbeing  Rhodiola rosea may act as a natural antidepressant and improve the way the blood-brain barrier transports serotonin and precursors of dopamine, which are crucial mood neurotransmitters [8,9]. Additionally, Rhodiola rosea may help to enhance levels of mood-boosting neurotransmitters by inhibiting the enzyme (monoamine oxidase) that breaks them down [10].
  • Supports the Brain’s Defenses Against Anxiety - Rhodiola rosea may also support the brain’s defenses against anxiety. In individuals with generalized anxiety disorder, one study found that supplementation with Rhodiola rosea for 10 weeks significantly lowered self-reported anxiety levels [11].

“These neuroprotective qualities indicate that Rhodiola rosea may maintain and support memory, focus, and learning.”

Rhodiola Supports Physical Energy

One of the most popular uses for Rhodiola rosea is for supporting optimal energy levels within the body. Current research suggests that these benefits may be due to the antioxidant capabilities of this powerful herb.

  • Adrenal Support – The adrenal gland is responsible for responding to stress by altering the levels of stress hormones (noradrenaline and cortisol) within the body [12]. When this gland becomes fatigued, it can no longer produce these vital hormones and leads to reduced energy. Through its adaptogenic roles, Rhodiola rosea may improve the stress response and beneficially regulate the way the adrenal glands secrete and maintain levels of noradrenaline and cortisol. As a result, Rhodiola may support physical energy.
  • Supports Athletic Performance – Current research suggests that Rhodiola rosea works as an adaptogen and increases levels of proteins that regulate stress [12]. The result is that these interactions indirectly increase levels of the main energy molecule, adenosine triphosphate (ATP). This provides more direct fuel to boost exercise performance. Rhodiola may also support exercise endurance by altering the way the body perceives effort [13].
  • Supports Libido – Research shows that sexual dysfunction may be a physical response that occurs when people are fatigued from chronic stress [12]. This is because stress hormones directly influence the way that the hypothalamus and pituitary gland release libido-influencing hormones. Clinical research indicates that Rhodiola may support sexual function in in those affected by stress [14].

“Rhodiola rosea may potentially have a two-fold effect on enhancing immunity.”

Rhodiola Maintains Immunity

It is well known that stress can lead to changes that ultimately weaken the immune system. Therefore, Rhodiola rosea may potentially have a two-fold effect on enhancing immunity.

  • Supports the Stress Response - Rhodiola may support immunity by reducing the effects of corticosteroids and catecholamines, which are stress hormones that can weaken the immune system when they are in overdrive [12,15].
  • Maintains Survival of Immune Cells - The phenolic compounds within the herb are antioxidants, which maintain immunity by supporting the survival of immune cells called T-cells and antibodies [16]. These immune cells target damaged cells, bacteria, viruses, and fungi which can harm the human body [17].

Rhodiola Supports Heart Health

  • Supports Health of Arteries – Excess inflammation can lead to the production of harmful oxygen radicals and an impaired ability to metabolize fats in the form of lipids. As a result, these lipids can accumulate, block arteries, and impede blood flow. Recent research suggests that an important molecule within Rhodiola rosea, called salidroside, may support lipid metabolism and arterial health [18].
  • Supports Protection during Heart Injury - Lack of blood flow to the heart results in an injury that can damage precious heart cells and lead to an oxygen-depleted state (hypoxia). Research indicates that salidroside, anactive molecule within Rhodiola rosea, can support protection of the heart from hypoxia by beneficially increasing sugar and protein uptake [19].
  • Supports Healthy Heart Function – Excess emotional stress can impair heart function and increase the risk of cardiovascular disease and heart attacks [20,21]. Clinical research suggests Rhodiola rosea may beneficially alter the stress response of the heart by interacting with opioid receptors [22]. This theory may correlate with the several research studies which suggest that Rhodiola rosea may support heart rate, healthy heart rhythm, and strength of heart muscle [23].

Recommended Dosages & Safety

In studies conducted on the safety of Rhodiola rosea extract for stress-related symptoms, dosages of up to 400 mg per day were found to be both safe and effective [5]. For symptoms of depression, dosages of 340-680 mg were found to be both tolerable and effective [9].

Though there are currently no studies that have found conclusive evidence of any adverse effects that are linked to Rhodiola rosea extract, one study reported no serious adverse effects associated with dosages of 400 mg per day [5]. The most common side effects reported were mild and consisted of neurological and gastrointestinal-related side effects.

References

1. Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001;6(3):293-302.

2. Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. 2010;17(7):481-493. doi:10.1016/j.phymed.2010.02.002

3. Kosakowska O, Bączek K, Przybył JL, et al. Antioxidant and Antibacterial Activity of Roseroot (Rhodiola rosea L.) Dry Extracts. Molecules. 2018;23(7):1767. Published 2018 Jul 18. doi:10.3390/molecules23071767

4. Kelly GS. Rhodiola rosea: a possible plant adaptogen. Altern Med Rev. 2001;6(3):293-302.

5. Edwards D, Heufelder A, Zimmermann A. Therapeutic effects and safety of Rhodiola rosea extract WS® 1375 in subjects with life-stress symptoms-- results of an open-label study. Phytother Res. 2012;26(8):1220-1225. doi:10.1002/ptr.3712

6. Kasper S, Dienel A. Multicenter, open-label, exploratory clinical trial with Rhodiola rosea extract in patients suffering from burnout symptoms. Neuropsychiatr Dis Treat. 2017;13:889-898. Published 2017 Mar 22. doi:10.2147/NDT.S120113

7. Ma GP, Zheng Q, Xu MB, et al. Rhodiola rosea L. Improves Learning and Memory Function: Preclinical Evidence and Possible Mechanisms. Front Pharmacol. 2018;9:1415. Published 2018 Dec 4. doi:10.3389/fphar.2018.01415

8. Saratikov SA, Krasnov EA. Rhodiola rosea is a Valuable Medicinal Plant (Golden root). Monograph Tomsk State University Press, Tomsk. 1987;252

9. Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmstrom C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry. 2007;61(5):343- 348.17990195

10. van Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann K. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. 2009;122(2):397-401. doi:10.1016/j.jep.2009.01.007

11. Bystritsky A, Kerwin L, Feusner JD. A pilot study of Rhodiola rosea (Rhodax) for generalized anxiety disorder (GAD). J Altern Complement Med. 2008;14(2):175-180. doi:10.1089/acm.2007.7117

12. Anghelescu IG, Edwards D, Seifritz E, Kasper S. Stress management and the role of Rhodiola rosea: a review. Int J Psychiatry Clin Pract. 2018;22(4):242-252. doi:10.1080/13651501.2017.1417442

13. Noreen EE, Buckley JG, Lewis SL, Brandauer J, Stuempfle KJ. The effects of an acute dose of Rhodiola rosea on endurance exercise performance. J Strength Cond Res. 2013;27(3):839-847. doi:10.1519/JSC.0b013e31825d9799

14. Edwards D, Eltbogen R, Noldner M. Stress-induced female sexual dysfunction: Beneficial effect of the Rhodiola rosea extract Rosalin (WS 1375). The Journal of Sexual Medicine. 2017;14, e196 (P-04-004). doi:10.1016/j.jsxm.2017.03.240

15. Dhabhar FS. Effects of stress on immune function: the good, the bad, and the beautiful. Immunol Res. 2014;58(2-3):193-210. doi:10.1007/s12026-014- 8517-0

16. Liu MW, Su MX, Zhang W, Zhang LM, Wang YH, Qian CY. Rhodiola rosea suppresses thymus T-lymphocyte apoptosis by downregulating tumor necrosis factor-α-induced protein 8-like-2 in septic rats. Int J Mol Med. 2015;36(2):386-398. doi:10.3892/ijmm.2015.2241

17. Kormosh N, Laktionov K, Antoshechkina M. Effect of a combination of extract from several plants on cell-mediated and humoral immunity of patients with advanced ovarian cancer. Phytother Res. 2006;20(5):424-425. doi:10.1002/ptr.1889

18. Pu WL, Zhang MY, Bai RY, et al. Anti-inflammatory effects of Rhodiola rosea L.: A review. Biomed Pharmacother. 2020;121:109552. doi:10.1016/j.biopha.2019.109552

19. Wu T, Zhou H, Jin Z, et al. Cardioprotection of salidroside from ischemia/reperfusion injury by increasing N-acetylglucosamine linkage to cellular proteins. European Journal of Pharmacology. 2009;613(1-3):93-99. doi:10.1016/j.ejphar.2009.04.012

20. Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study. BMJ. 2019;365:l1850. Published 2019 Apr 23. doi:10.1136/bmj.l1850

21. Connelly KA, MacIsaac AI, Jelinek VM. Stress, myocardial infarction, and the "tako-tsubo" phenomenon. Heart. 2004;90(9):e52. doi:10.1136/hrt.2004.038851

22. Lishmanov IuB, Naumova AV, Afanas'ev SA, Maslov LN. Contribution of the opioid system to realization of inotropic effects of Rhodiola rosea extracts in ischemic and reperfusion heart damage in vitro. Eksp Klin Farmakol. 1997 May-Jun;60(3):34-6. Russian. PMID: 9324395.

23. Timpmann S, Hackney AC, Tamm M, Kreegipuu K, Unt E, Ööpik V. Influence of Rhodiola rosea on the heat acclimation process in young healthy men. Appl Physiol Nutr Metab. 2018;43(1):63-70. doi:10.1139/apnm-2017-0372

24. Maslov LN, Lishmanov IuB. Cardioprotective and antiarrhythmic properties of Rhodiolae roseae preparations. Eksp Klin Farmakol. 2007;70(5):59-67.